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(24-361C)金太阳2024届高三英语下学期联考(开学考)贵州省
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Plastic,which is now common,contains endocrine-disrupting chemicals,or EDCs(内分泌干扰物),that has been linked to increased risk of many chronic diseases.Parental exposureto EDCs,for example,has been shown to cause metabolic(新陈代谢的)disorders,includingobesity and diabetes,in the later generations.
Led by Changcheng Zhou,a professor of biomedical sciences in the School of Medicine atthe University of California,the researchers investigated the impact of fathers'exposure to aphthalate called dicyclohexyl phthalate,or DCHP(邻苯二甲酸二环己酯),on the metabolichealth of first generation(F1)and second generation(F2)in mice.Phthalates are chemicalsused to make plastic more durable.
The researchers found that fathers'DCHP exposure for four weeks led to high insulin(胰岛素)resistance and impaired insulin signaling in F1.The same effect,but weaker,wasseen in F2.
“We found fathers'exposure to EDCs may have intergenerational and transgenerationaldetrimental effects on the metabolic health of their later generations,”Zhou said.“To the bestof our knowledge,our study is the first to demonstrate this.”
In the case of fathers'exposure in the study,intergenerational effects are changes thatoccur due to direct exposure to a stressor,such as exposure to DCHP of fathers(F0 generation)and his Fl generation.Transgenerational effects are changes passed down tolater generations that are not directly exposed to the stressor(for example,F2 generation).
“This suggests that fathers’DCHP exposure can lead to sex-specific transgenerationaleffects on the metabolic health of their later generations,”Zhou said.
Zhou stressed that the impact of exposure to DCHP on human health is not wellunderstood,even though DCHP is widely used in a variety of plastic products and has beendetected in food,water,and indoor particulate matter.
“It's best to minimize our use of plastic products,"Zhou said."This can also help reduceplastic pollution,one of our most pressing environmental issues.”
(24-361C)金太阳2024届高三英语下学期联考(开学考)贵州省
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